Analyzing Simultaneous Targeting of PD-1 & FcγRIIb to Discover Challenges & Mitigations in the Absence of Double Humanized Mouse Models
Time: 9:00 am
day: Conference Day One
Details:
- Demonstrating the biological relevance of simultaneously targeting PD-1 and FcγRIIb to modulate autoimmune disease pathways for enhanced therapeutic efficacy
- Overcoming the lack of double-humanized PD-1/FcγRIIb models by developing alternative approaches to enable thorough drug evaluation
- Optimizing mouse model development for PD-1 agonist screening by balancing biological relevance with technical constraints to improve preclinical predictability
